Publications

Whole-mouse clearing and imaging at the cellular level with vDISCO. Ruiyao Cai,Zeynep Ilgin Kolabas, Chenchen Pan,Hongcheng Mai, Shan Zhao, Doris Kaltenecker, Fabian F. Voigt, Muge Molbay, Tzu-lun Ohn,Cécile Vincke, Mihail I. Todorov, Fritjof Helmchen, Jo A. Van Ginderachter & Ali Ertürk Nat protoc (Jan 2023)

Spatial proteomics in three-dimensional intact specimens. HS Bhatia, AD Brunner, F Öztürk, S Kapoor, Z Rong…A Ertürk Cell (Dec 2022)

Scalable tissue labeling and clearing of intact human organs. H Mai, Z Rong, S Zhao, R Cai, H Steinke, I Bechmann, A Ertürk. Nature Protocols (2022)

Neuroimmune cardiovascular interfaces control atherosclerosis. SK Mohanta, L Peng, Y Li, S Lu, T Sun, L Carnevale, M Perrotta, Z Ma, ..Ertürk A…Habenicht A. Nature (2022)

Tissue clearing. DS Richardson, W Guan, K Matsumoto, C Pan, K Chung, A Ertürk, …
Nature Reviews Methods Primers (2021)

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. T Gruber, C Pan, RE Contreras, T Wiedemann, DA Morgan, …A Ertürk…C García-Cáceres. Cell metabolism (2021)

A guidebook for DISCO tissue clearing. M Molbay, ZI Kolabas, MI Todorov, TL Ohn, A Ertürk
Molecular Systems Biology (2021)

Wang X, Lou N, Eberhardt A, Yang Y, Kusk P, Xu Q, Förstera B, Peng S, Shi M, Ladrón-de-Guevara A, Delle C,  Sigurdsson B, L. R. Xavier, A, Ertürk A, T. Libby R, Chen L, S. Thrane A, Nedergaard M. An ocular glymphatic clearance system removes β-amyloid from the rodent eye. Science Translational Medicine. 2020 Mar | PDF

Todorov M.I*., Paetzold J.C.*, Schoppe O, Tetteh G, Shit S, Efremov V, Todorov-Völgyi K, Düring M, Dichgans M, Piraud M, Menze B, Ertürk A. Machine learning analysis of whole mouse brain vasculature. Nat Methods. 2020 Mar | PDF

Zhao S, Todorov M.I., Cai R, AI-Maskari R, Steinke H, Kemter E, Mai H, Rong Z. Warmer M, Stanic K, Schoppe O, Paetzold J.C, Gesierich B, Wong M.N, Huber T.B, Duering M, Thomasruns O, Menze B, Ertürk A. Cellular and Molecular Probing of Intact Human Organs. Cell. 2020 | PDF

Ueda H.R, Ertürk A, Chung K, Gradinaru V, Chédotal A, Tomancak P, Keller, P.J. Tissue clearing and its applications in neuroscience. Nat Rev Neurosci. 2020 Feb | PDF

Pan C*, Schoppe O*, Parra-Damas A*, Cai R, Todorov MI, Gondi G, von Neubeck B, Böğürcü-Seidel N, Seidel S, Sleiman K, Veltkamp C, Förstera B, Mai H, Rong Z, Trompak O, Ghasemigharagoz A, Reimer MA, Cuesta AM, Coronel J, Jeremias I, Saur D, Acker-Palmer A, Acker T, Garvalov BK, Menze B, Zeidler R, Ertürk A. Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body. Cell. 2019 Dec | PDF

Cai R*, Pan C*, Ghasemigharagoz A, Todorov MI, Förstera B, Zhao S, Bhatia HS, Parra-Damas A, Mrowka L, Theodorou D, Rempfler M, Xavier ALR, Kress BT, Benakis C, Steinke H, Liebscher S, Bechmann I, Liesz A, Menze B, Kerschensteiner M, Nedergaard M, Ertürk A. Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections. Nat Neurosci. 2019 Feb | PDF

Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nat Neurosci. 2019 | PDF

von Neubeck B, Gondi G, Riganti C, Pan C, Parra Damas A, Scherb H, Ertürk A, Zeidler R. An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo. Int J Cancer. 2018 | PDF

Llovera G, Benakis C, Enzmann G, Cai R, Arzberger T, Ghasemigharagoz A, Mao X, Malik R, Lazarevic I, Liebscher S, Ertürk A, Meissner L, Vivien D, Haffner C, Plesnila N, Montaner J, Engelhardt B, Liesz A. The choroid plexus is a key cerebral invasion route for T cells after stroke. Acta Neuropathol. 2017 Dec | PDF

Garvalov BK, Ertürk A. Seeing whole-tumour heterogeneity. Nat Biomed Eng. 2017 | PDF

Pan C*, Cai R*, Quacquarelli FP*, Ghasemigharagoz A, Lourbopoulos A, Matryba P, Plesnila N, Dichgans M, Hellal F, Ertürk A. Shrinkage-mediated imaging of entire organs and organisms using uDISCO. Nat Methods. 2016 Oct | PDF

Ertürk A, Mentz S, Stout EE, Hedehus M, Dominguez SL, Neumaier L, Krammer F, Llovera G, Srinivasan K, Hansen DV, Liesz A, Scearce-Levie KA, Sheng M. Interfering with the Chronic Immune Response Rescues Chronic Degeneration After Traumatic Brain Injury. J Neurosci. 2016 | PDF

Lourbopoulos A*, Ertürk A*, Hellal F*. Microglia in action: how aging and injury can change the brain’s guardians. Front Cell Neurosci. 2015 | PDF

Ertürk A, Wang Y, Sheng M. Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms. J Neurosci. 2014 Jan.

Chen Y, Wang Y, Ertürk A, Kallop D, Jiang Z, Weimer RM, Kaminker J, Sheng M. Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons. Neuron. 2014 Jul 16.

Ertürk A, Lafkas D, Chalouni C. Imaging cleared intact biological systems at a cellular level by 3DISCO. J Vis Exp. 2014 Jul.

Sheng M, Ertürk A. Long-term depression: a cell biological view. Philos Trans R Soc Lond B Biol Sci. 2013 Dec.

Ertürk A, Bradke F. High-resolution imaging of entire organs by 3-dimensional imaging of solvent cleared organs (3DISCO). Exp Neurol. 2013 Apr.

Ertürk A, Becker K, Jährling N, Mauch CP, Hojer CD, Egen JG, Hellal F, Bradke F, Sheng M, Dodt HU. Three-dimensional imaging of solvent-cleared organs using 3DISCO. Nature Protocols. 2012 Nov.

Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F. Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nature Medicine2011 Dec.

Usher LC, Johnstone A, Ertürk A, Hu Y, Strikis D, Wanner IB, Moorman S, Lee JW, Min J, Ha HH, Duan Y, Hoffman S, Goldberg JL, Bradke F, Chang YT, Lemmon VP, Bixby JL. A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration. J Neurosci. 2010 Mar.

Ylera B*, Ertürk A*, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F. Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon. Curr Biol. 2009 Jun.