A fundamental challenge in modern science is to understand how the brain functions in health and disease. We are interested in understanding cellular and molecular mechanisms leading to chronic neurodegeneration after acute brain injuries – particularly brain trauma. To this end, we utilize – cutting-edge techniques including 3D imaging of entire cleared brains (recently developed by us), rabies virus tracing of neuronal networks, optogenetics and in vivo 2-photon imaging. Our overall goal is to determine molecular players that can be targeted (genetically or pharmacologically) to develop effective ways to halt chronic neurodegeneration after acute brain injuries.
>> The first article of e-lab has been published in Nature Methods. This method called uDISCO, and it allows making entire adult rodents transparent for whole-body imaging at subcellular resolution. uDISCO provides the basis to map neuronal, glial, and vascular connections in the entire lab animals and potentially in deceased human brains. The work is highlighted by media worldwide including New York Times, Wall Street Journal, NBC news, Discovery Channel, Business Insider, Nature and Science magazines.